Turn a formulation into a campaign.

1. 01

   Start from a formulation

   Choose Open in Optimize on a formulation report, pick the candidate, and DeepC restates it as the optimisation target.

   OT01F01 as the optimisation targetimmediate-release tablet · oral

   • Metformin hydrochlorideActive ingredient500 mg
   • Microcrystalline celluloseBinder, filler120 mg
   • Povidone K30Binder12 mg
   • Croscarmellose sodiumDisintegrant18 mg
   • Magnesium stearateLubricant4.5 mg

2. 02

   Set the objectives and the design space

   Up to four objectives, each to maximise, minimise or hold on a target, and 1 to 5 experiments per round. DeepC proposes the factors and their ranges as an editable card, checks each against regulatory precedent for the route and dosage form, and you confirm them to create the campaign.

   DS01Design spaceMaximise dissolution at 30 min, one experiment per round

   • binder_pct1.0 – 4.0 %feasible
   • lubricant_pct0.25 – 1.5 %feasible
   • disintegrant_pct2.0 – 8.0 %feasible
   • compression_kn5 – 20 kNunscreened

   Experiments per round (bench capacity)1

3. 03

   Run the loop

   Each round proposes the next experiments from a statistical model of your results, and every proposed value comes from that model. You enter the bench results, which are stored exactly as entered, and the next round learns from them. When no admissible experiment remains, the round says so.

   Next experiment

   binder_pct2.156round 8lubricant_pct0.7353round 8compression_kn5.7049round 8disintegrant_pct6.0147round 8

   Predicted89.23 ± 5.34model

   model prediction over the runs so far, not a measurement

4. 04

   See where you stand

   Convergence, the next experiment, the runs ledger, the feasible region, the trade-offs between competing objectives, and response surfaces you can slice by factor.

   Convergence

   Best so far

   Pareto front

   Measured runs

   y: tensile strength (MPa)

5. 05

   Keep the record

   Each campaign keeps a tamper-evident ledger of its settings, proposals and results, and campaigns are listed in the Library.

   Runs

   #8completedseed 7

   #7completedseed 6

   #6completedseed 5

   #5completedseed 4

The campaign shown is an illustrative example.